Background: Concern has been expressed about the process of consent to clinical trials, particularly in phase I “first-in-man” trials. Trial participant information sheets are often lengthy and technical. Content-based readability testing of sheets, which is often required to obtain research ethics approval for trials in the USA, is limited and cannot indicate how information will perform. Methods: An independent-groups design was used to study the user-testing performance of the participant information sheet from the phase I TGN1412 trial. Members of the (...) public were asked to read it, then find and demonstrate understanding of 21 key aspects of the trial. The participant information sheet was then rewritten, redesigned and tested on 20 members of the public, using the same 21-item questionnaire. Results: On the original TGN1412 participant information sheet, participants could not find answers and some of the found information was not understood. Six of 21 questions, including those relating to placebo, follow-up visits and the emergency phone number, were found by eight or fewer of 10 participants. The revised information sheet performed better, with the answers to 17 of 21 questions found and understood by all 20 participants. Conclusions: Tests showed that the TGN1412 participant information sheet may not inform participants adequately for consent. Revising its content and design led to significant improvements. Writers of materials for trial participants should take account of good practice in information design. Performance-based user testing may be a useful method to indicate strengths and weaknesses in trial materials. (shrink)

This volume has 41 chapters written to honor the 100th birthday of Mario Bunge. It celebrates the work of this influential Argentine/Canadian physicist and philosopher. Contributions show the value of Bunge’s science-informed philosophy and his systematic approach to philosophical problems. The chapters explore the exceptionally wide spectrum of Bunge’s contributions to: metaphysics, methodology and philosophy of science, philosophy of mathematics, philosophy of physics, philosophy of psychology, philosophy of social science, philosophy of biology, philosophy of technology, moral philosophy, social and political (...) philosophy, medical philosophy, and education. The contributors include scholars from 16 countries. Bunge combines ontological realism with epistemological fallibilism. He believes that science provides the best and most warranted knowledge of the natural and social world, and that such knowledge is the only sound basis for moral decision making and social and political reform. Bunge argues for the unity of knowledge. In his eyes, science and philosophy constitute a fruitful and necessary partnership. Readers will discover the wisdom of this approach and will gain insight into the utility of cross-disciplinary scholarship. This anthology will appeal to researchers, students, and teachers in philosophy of science, social science, and liberal education programmes. 1. Introduction Section I. An Academic Vocation Section II. Philosophy Section III. Physics and Philosophy of Physics Section IV. Cognitive Science and Philosophy of Mind Section V. Sociology and Social Theory Section VI. Ethics and Political Philosophy Section VII. Biology and Philosophy of Biology Section VIII. Mathematics Section IX. Education Section X. Varia Section XI. Bibliography. (shrink)

In this article we explore multiple change operators, i.e., operators in which the epistemic input is a set of sentences instead of a single sentence. We propose two types of change: prioritized change, in which the input set is fully accepted, and symmetric change, where both the epistemic state and the epistemic input are equally treated. In both kinds of operators we propose a set of postulates and we present different constructions: kernel changes and partial meet changes.

Understanding disgustingness is philosophically important partly because claims about disgustingness play a prominent role in moral discourse and practice. It is also important because disgustingness has been used to illustrate the promise of "neo-sentimentalism." Recently developed by moral philosophers such as David Wiggins, John McDowell, Simon Blackburn, Justin D'Arms and Dan Jacobson, neo-sentimentalism holds that for a thing to be disgusting is for it to be "appropriate" to respond to it with disgust. In this paper, I argue that from what (...) we currently know about the disgust response, these accounts are mistaken. Instead, disgustingness is best understood as a descriptive property: fundamentally, things that are disgusting-for-S are things that possess triggers for S's disgust mechanism. Theoretically, my account puts pressure on neo-sentimentalists to show that the responses they appeal to can anchor normative properties. Practically, my account shows that we must abandon authoritative claims that certain things really are--or are not--disgusting. (shrink)

Understanding disgustingness is philosophically important partly because claims about disgustingness play a prominent role in moral discourse and practice. It is also important because disgustingness has been used to illustrate the promise of “neo‐sentimentalism.” Recently developed by moral philosophers such as David Wiggins, John McDowell, Simon Blackburn. Justin D'Arms and Dan Jacobson, neo‐sentimentalism holds that for a thing to be disgusting is for it to be “appropriate” to respond to it with disgust. In this paper, I argue that from what (...) we currently know about the disgust response. these accounts are mistaken. Instead, disgustingness is best understood as a descriptive property: fundamentally, things that are disgusting‐for‐S are things that possess triggers for S's disgust mechanism. Theoretically, my account puts pressure on neo‐sentimentalists to show that the responses they appeal to can anchor normative properties. Practically, my account shows that we must abandon authoritative claims that certain things really are—or are not—disgusting. (shrink)

In some languages every statement must contain a specification of the type of evidence on which it is based: for example, whether the speaker saw it, or heard it, or inferred it from indirect evidence, or learnt it from someone else. This grammatical reference to information source is called 'evidentiality', and is one of the least described grammatical categories. Evidentiality systems differ in how complex they are: some distinguish just two terms (eyewitness and noneyewitness, or reported and everything else), while (...) others have six or even more terms. Evidentiality is a category in its own right, and not a subcategory of epistemic or some other modality, nor of tense-aspect. Every language has some way of referring to the source of information, but not every language has grammatical evidentiality. In English expressions such as I guess, they say, I hear that, the alleged are not obligatory and do not constitute a grammatical system. Similar expressions in other languages may provide historical sources for evidentials. True evidentials, by contrast, form a grammatical system. In the North Arawak language Tariana an expression such as "the dog bit the man" must be augmented by a grammatical suffix indicating whether the event was seen, or heard, or assumed, or reported. This book provides the first exhaustive cross-linguistic typological study of how languages deal with the marking of information source. Examples are drawn from over 500 languages from all over the world, several of them based on the author's original fieldwork. Professor Aikhenvald also considers the role evidentiality plays in human cognition, and the ways in which evidentiality influences human perception of the world.. This is an important book on an intriguing subject. It will interest anthropologists, cognitive psychologists and philosophers, as well as linguists. (shrink)

On Zakī Najīb Maḥmūd ; Egyptian philosopher and thinker.

One of the traditional ways mathematical ideas and even new areas of mathematics are created is from experiments. One of the best-known examples is that of the Fermat hypothesis, which was conjectured by Fermat in his attempts to find integer solutions for the famous Fermat equation. This hypothesis led to the creation of a whole field of knowledge, but it was proved only after several hundred years. This book, based on the author's lectures, presents several new directions of mathematical research. (...) All of these directions are based on numerical experiments conducted by the author, which led to new hypotheses that currently remain open, i.e., are neither proved nor disproved. The hypotheses range from geometry and topology (statistics of plane curves and smooth functions) to combinatorics (combinatorial complexity and random permutations) to algebra and number theory (continuous fractions and Galois groups). For each subject, the author describes the problem and presents numerical results that led him to a particular conjecture. In the majority of cases there is an indication of how the readers can approach the formulated conjectures (at least by conducting more numerical experiments). Written in Arnold's unique style, the book is intended for a wide range of mathematicians, from high school students interested in exploring unusual areas of mathematics on their own, to college and graduate students, to researchers interested in gaining a new, somewhat nontraditional perspective on doing mathematics. In the interest of fostering a greater awareness and appreciation of mathematics and its connections to other disciplines and everyday life, MSRI and the AMS are publishing books in the Mathematical Circles Library series as a service to young people, their parents and teachers, and the mathematics profession. Titles in this series are co-published with the Mathematical Sciences Research Institute (MSRI). (shrink)

In The Quantum Self, Danah Zohar argues that the insights of modem physics can illuminate our understanding of everyday life -- our relationships to ourselves, to others, and to the world at large. Guiding us through the strange and fascinating workings of the subatomic realm to create a new model of human consciousness, the author addresses enduring philosophical questions. Does the new physics provide a basis by which our consciousness might continue beyond death? How does the material world (for instance, (...) ugly inner cities) impinge upon our sense of self? Is there a subatomic wellspring from which our creativity, our empathy with others, and our feelings of unity with the inanimate world originate?Most important, Zohar shows how the vitality of the new physics combats the alienation and fragmentation of twentieth-century life, and replaces it with a model of reality in which the universe itself may possess a type of consciousness, of which human consciousness is one expression. (shrink)

This paper's purpose is to assess how management's perceptions regarding certain aspects of environmental reporting relate to the firm's actual reporting strategy. Toward that end, we propose a model where a firm's environmental disclosure is conditional upon executive assessments of corporate concerns. The study relies on a survey that was sent to environmental management executives from European and North American multinational firms enquiring about the determinants of corporate environmental disclosure. Responses from these executives were then contrasted with their firms' actual (...) environmental reporting practices, which was measured using a comprehensive multi-criteria grid. Results show that there is a relationship between environmental managers' attitudes toward various stakeholder groups and how those managers respond to the stakeholders via the decision to disclose and the actual disclosures made. Our model provides a perspective as to how a firm responds to the numerous stakeholders to whom it must be accountable. This accountability in turn relates to how the company communicates its actions to society in order to achieve or maintain its social legitimacy. (shrink)

Criminal jurisdiction; international criminal courts.

The first volume to offer a thorough and systematic account of evidentiality and the expression of information source, Illustrated with extensive data from a range of typologically diverse languages, Introductory chapter offers practical advice for fieldworkers investigating evidentially, Interdisciplinary in nature with insights from typology, semantics, pragmatics, language description, anthropology, cognitive psychology, and psycholinguistics Book jacket.

Knowledge can be expressed in language using a plethora of grammatical means. Four major groups of meanings related to knowledge are Evidentiality: grammatical expression of information source; Egophoricity: grammatical expression of access to knowledge; Mirativity: grammatical expression of expectation of knowledge; and Epistemic modality: grammatical expression of attitude to knowledge. The four groups of categories interact. Some develop overtones of the others. Evidentials stand apart from other means in many ways, including their correlations with speech genres and social environment. This (...) essay presents a framework which connects the expression of knowledge across the world's languages in a coherent way, showing their dependencies and complexities, and pathways of historical development in various scenarios, including language obsolescence. (shrink)

Literature; hermeneutics; theory, etc.; history and criticism.

Upshot: We seek to address several questions and statements made in the commentaries by elaborating on the four main aspects of the M-N-L framework. Before doing so, we discuss the issue of constructivist teaching in the context of schools. We conclude by hypothesizing on what would be lost in the M-N-L framework by taking constructivism out of the picture.

Context: Constructivist teachers who find themselves working within an educational system that adopts a realist epistemology, may find themselves at odds with their own beliefs when they catch themselves paying closer attention to the knowledge authorities intend them to teach rather than the knowledge being constructed by their learners. Method: In the preliminary analysis of the mathematical learning of six low-performing Year 7 boys in a Maltese secondary school, whom one of us taught during the scholastic year 2014-15, we constructed (...) a conceptual framework which would help us analyze the extent to which he managed to be sensitive to constructivism in a typical classroom setting. We describe the development of the framework M-N-L as a viable analytical tool to search for significant moments in the lessons in which the teacher appeared to engage in what we define as “constructivist teaching” during mathematics lessons. The development of M-N-L is part of a research program investigating the way low-performing students make mathematical sense of new notation with the help of the software Grid Algebra. Results: M-N-L was found to be an effective instrument which helped to determine the extent to which the teacher was sensitive to his own constructivist beliefs while trying to negotiate a balance between the mathematical concepts he was expected to teach and the conceptual constructions of his students. Implications: One major implication is that it is indeed possible for mathematics teachers to be sensitive to the individual constructions of their learners without losing sight of the concepts that society, represented by curriculum planners, deems necessary for students to learn. The other is that researchers in the field of education may find M-N-L a helpful tool to analyze CT during typical didactical situations established in classroom settings. (shrink)

Shinra Myojin and Buddhist Networks of the East Asian “Mediterranean” by Sujung Kim. University of Hawai’i Press, 2020. 194pp. Hb. $80.00, ISBN-13: 9780824877996; Pb. $28.00, ISBN-13: 9780824888442.

Initial responses to questionnaires used to assess participants' understanding of informed consent for malaria vaccine trials conducted in the United States and Mali were tallied. Total scores were analyzed by age, sex, literacy (if known), and location. Ninety-two percent (92%) of answers by United States participants and 85% of answers by Malian participants were correct. Questions more likely to be answered incorrectly in Mali related to risk, and to the type of vaccine. For adult participants, independent predictors of higher scores (...) were younger age and female sex in the United States, and male sex in Mali. Scores in the United States were higher than in Mali (P = 0.005). Despite this difference participants at both sites were well informed overall. Although interpretation must be qualified because questionnaires were not intended as research tools and were not standardized among sites, these results do not support concerns about systematic low understanding among research participants in developing versus developed countries. (shrink)

This book studies the interfaces of ethics, economics, and politics. Public policy issues involve all three of these subjects. Although it may be seen as suggesting the nucleus of a joint university course, the book is accessible to and should interest all those concerned with political decisions. Any such decision needs a criterion for judging whether one action or outcome is better than another. Even a dictator must to some extent be concerned about the economic elfare of the citizens; and (...) a democratic government more so. But how is a person's economic welfare to be judged? Furthermore, any political decision affects the economic welfare of different people differently. How then is the welfare of a community to be judged? This is an ethical question. Underlying any coherent public policy there must be a relevant moral code. (shrink)

This book studies the interfaces of ethics, economics, and politics. Public policy issues involve all three of these subjects. Although it may be seen as suggesting the nucleus of a joint university course, the book is accessible to and should interest all those concerned with political decisions. Any such decision needs a criterion for judging whether one action or outcome is better than another. Even a dictator must to some extent be concerned about the economic welfare of the citizens; and (...) a democratic government more so. But how is a person's economic welfare to be judged? Furthermore, any political decision affects the economic welfare of different people differently. How then is the welfare of a community to be judged? This is an ethical question. Underlying any coherent public policy there must be a relevant moral code. (shrink)

Memoirs of Saʻīd Pīshdād, 1955 or 1956-; school administrators professional ethics, Iran.

Ian Little has been one of the most significant British contributors to economics in the post-war era. His contributions to Welfare Economics and Development Economics have been highly influential and well-regarded throughout the world. This book is a fascinating insight into the personal and intellectual development of Professor Little, containing both the most important articles of his working life and autobiographical chapters.